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Formulation of creams with betamethasone dipropionate: evaluation of chemical stability

Băiţan, M.; Gafiţanu, E.; Lionte, M.; Moisuc, L.ăc.ăm.

Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 114(2): 600-604

2010

ISSN/ISBN: 0048-7848
PMID: 20701012
Document Number: 639351
The aim of this study was to investigate how the different excipients influenced the chemical stability of betamethasone dipropionate in creams. The chemical stability was evaluated by analyzing betamethasone related substance content. Transcutol is the excipient ensuring maximum stability to betamethasone. Incompatibilities between betamethasone dipropionate and hexylene glycol were observed. The pH values in the weak acid range confer chemical stability to betamethasone.

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