Effects of atorvastatin on heart mitochondrial function and coenzyme Q content in the experiment
Kucharska, J.; Ulicna, O.; Gvozdjakova, A.; Vancova, O.; Waczulikova, I.; Bozek, P.; Bada, V.
Bratislavske Lekarske Listy 112(11): 603-604
2011
ISSN/ISBN: 0006-9248 PMID: 22180983 Document Number: 653676
We focused on determination of whether atorvastatin: 1) reduces CoQ content, 2) impairs mitochondrial function and 3) induces dose-dependent changes. Although the high dose of atorvastatin exerted a beneficial effect on the lipid peroxidation in plasma, coenzyme Q content was reduced and heart mitochondrial function was impaired. Physicians should be aware when prescribing statins mainly in higher doses to the patients with co-existing proved or supposed CoQ10 deficiency resulting from age-related decline, and metabolic or mitochondrial diseases (Ref. 3).