The role of ADME evaluation in translation research of innovative drug
Liu, Y.; Hong, L.; Yu, L-Shan.; Jiang, H-Di.; Chen, J-Zhong.; Meng, Q.; Chen, S-Qing.; Zeng, S.
Yao Xue Xue Bao 46(1): 19-29
2011
ISSN/ISBN: 0513-4870 PMID: 21465804 Document Number: 653380
New Chemical Entities (NCEs) development is a systematic long-term project that involves multiple disciplines. The translation research will help to build an advanced R&D system from the basic laboratory research, preclinical studies and clinical evaluation to clinical application of drug, for the purpose of shortening the R&D cycle and accelerate the launch of new drugs. In new drug R&D and its clinical application, drug disposition (absorption, distribution, metabolism, excretion, ADME) properties are important criteria for assessing drug-likeness of candidates. ADME evaluation of NCEs plays an important role in the translation research throughout innovative drug R&D process. Therefore, ADME evaluation at the early stage of drug design and development will be helpful to improve the success rate and reduce costs, and further access to safe, effective drugs.