Effect of haloperidol and risperidone on neuromarkers and indices of endothelial dysfunction in patients with acute schizophrenia
Govorin, N.V.; Vasil'eva, A.I.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 111(3): 54-57
2011
ISSN/ISBN: 1997-7298 PMID: 21423116 Document Number: 652907
Effect of haloperidol and risperidone on positive, negative, neurocognitive disorders, biological parameters and neurodestruction-neuroreparation processes have been studied in 23 patients with the first episode of paranoid schizophrenia. Risperidone, along with high therapeutic effect towards positive, negative, neurocognitive disorders, is able to reduce brain neurodestruction markers as well as to improve protective-compensatory processes directed to the neuroplasticity restoration. There were correlations between biological parameters studied: the higher were levels of GFAP and antibodies to NR2 subunit of NMDA receptors, the higher were BDNF and NO values. The association between parameters studied and psychopathological disorders measured with the PANSS has been found in patients treated with risperidone. The mentioned correlations were not observed in patients treated with haloperidol.