Bioequivalence of anvifen and phenibut
Zhezlova, A.V.; Belolipetskaia, V.G.; Blagodatskikh, S.V.; Merkulova, E.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 74(5): 43-44
2011
ISSN/ISBN: 0869-2092 PMID: 21809698 Document Number: 652897
An open randomized crossover test on 18 healthy volunteers was used to study the pharmacokinetics of anvifen (acting substance, aminophenylbutyric acid) manufactured in capsules at the Joint-Stock Company "Antiviral" (Russia). The test was performed after single peroral administration in comparison with phenibut tablets of the same manufacturer. The concentration of unchanged aminophenylbutiric acid in the blood plasma was measured by HPLC with UV detection. It is established that anvifen and phenibut are bioequivalent in terms of pharmacokinetics.