Anemia and chronic kidney failure
Stepánková, S.
Vnitrni Lekarstvi 57(7-8): 631-634
2011
ISSN/ISBN: 0042-773X PMID: 21877597 Document Number: 652666
Anaemia is a common manifestation ofa chronic kidney failure. It is caused by a relative shortage oferythropoetine (EPO) and iron deficite with its metabolism defect. The most important factor in the pathogenesis of iron metabolism defects is hepcidin. Hepcidin maintains the iron homeostasis in the organism. The therapy of renal anaemia is based on the iron substitution and erythropoiesis stimulating agents (ESA) application. The most common reasons for the resistance to ESA are (after iron deficiency) inflammation and malnutrition.