Tamoxifen/norfloxacin interaction leading to QT interval prolongation in a female patient with extracranial meningioma
Slovacek, L.; Priester, P.; Petera, J.; Slanska, I.; Kopecky, J.
Bratislavske Lekarske Listy 112(6): 353-354
2011
ISSN/ISBN: 0006-9248 PMID: 21692412 Document Number: 652263
The authors report on a case of tamoxifen/norfloxacin interaction leading to QT interval prolongation in an 83-year-old female patient with extracranial meningioma treated with radiation and hormonal therapy (with Tamoxifen). This case report highlights the potential risk of tamoxifen causing depression of electrical impulse in sinoatrial node, leading to symptomatic sinus bradycardia with prolonged QT interval. At the same time it indicates the need to be on the look out for drug interactions (in our case between tamoxifen and norfloxacin), as well as to be aware of other drugs possibly inducing QT interval prolongation (Fig. 2, Ref. 7).