Development and evaluation of mucoadhesive buccal patches of flurbiprofen
Mishra, S.K.; Garud, N.; Singh, R.
Acta Poloniae Pharmaceutica 68(6): 955-964
2011
ISSN/ISBN: 0001-6837 PMID: 22125962 Document Number: 652030
In the present study, an attempt was made to formulate mucoadhesive buccal patches of flurbiprofen (FBN) in order to enhance solubility. Solubity enhancement was attempted by making solid dispersion of drug with beta-CD (cyclodextrin). Initially preformulation were carried out using reported methods. Buccal patches were prepared by solvent casting technique using polymers like polyvinyl alcohol (PVA), sodium carboxymethyl cellulose (SCMC), and hydroxypropyl methylcellulose (HPMC). The prepared patches were evaluated for their weight variation, thickness, folding endurance, surface pH, swelling index, in vitro residence time, in vitro permeation studies, drug content uniformity and bioadhesion test.