Human muscle-derived stem cells. Effectiveness in animal models of faecal incontinence. Research scheduling
Mongardini, M.; Lisi, A.; Giofrè, M.; Ledda, M.; Grimaldi, S.; Scarnò, M.; Trucchia, A.; Kyriacou, K.A.; Kyriacou, A.K.; Badiali, D.; Custureri, F.
Il Giornale di Chirurgia 32(8-9): 357-360
2011
ISSN/ISBN: 0391-9005 PMID: 22018255 Document Number: 650085
Researchers believe that human muscle-derived cells are able to restore leak-point pressure to normal levels by differentiating into new muscle fibres that prevent anal sphincter muscle atrophy. Laboratory data are needed to identify exactly how these cells work to regenerate muscle. The objective of this study is to test whether stem cells can be employed to treat internal anal sphincter (IAS) injuries in humans; to this end, this work will use a two-step process to study: first, the effectiveness of the treatment in a sample of animals with artificial injuries to the IAS and then to verify the results in a population of selected humans affected by pathology.