Pathogenesis of NSAIDs-induced gastrointestinal ulcers
Yoshikawa, T.; Naito, Y.
Nihon Rinsho. Japanese Journal of Clinical Medicine 69(6): 995-1002
2011
ISSN/ISBN: 0047-1852 PMID: 21688618 Document Number: 649269
It is necessary for some conditions to occur at the same time so that NSAIDs-induced gastrointestinal ulcers occur. The definite condition that is necessary for the development of ulcers by NSAIDs is the direct injury with NSAIDs and the presence and influences of the luminal factors, including gastric acid, bacteria, and bile acids. The pathologic central mechanism is the inhibition of cyclooxygenase, the disturbance of microcirculation and pro-apoptotic signaling. At all events, it is a theme for gastroenterologists to establish a mean to prevent the gastrointestinal ulcers induced by NSAIDs.