Possible role of nitric oxide in newborns weight gain disorder caused by prolonged dexamethasone therapy (experimental study)
Sinauridze, O.D.; Gongadze, N.V.; Kvachadze, I.D.; Bekaia, G.L.
Georgian Medical News 191: 49-53
2011
ISSN/ISBN: 1512-0112 PMID: 21436480 Document Number: 649257
Experimental studies on rats revealed that the newborns growth retardation, caused by long-term treatment with Dexamethasone in the neonatal period, can be prevented by the simultaneous with dexamethasone administration of the nitric oxide donor--L-arginine. This indicates that the mentioned Dexamethasone-induced growth disorder is caused by inhibition of Nitric Oxide Synthases activity.
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