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Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia

Zarubina, I.V.; Shabanov, P.D.

Eksperimental'naia i Klinicheskaia Farmakologiia 74(2): 8-15

2011

ISSN/ISBN: 0869-2092
PMID: 21476278
Document Number: 649177
The polypeptide drug cortexin and the synthetic peptide drug cortagen accelerate the recovery of disturbed individual behavior of ischemic rats with different resistance to hypoxia (high and low resistant rats). In addition, both drugs prevented an excessive activation of lipid peroxidation and a decrease in the antioxidant activity in the brain tissues. The obtained results suggest that cortexin and cortagen can be used for increasing the efficacy of neuroprotective therapy in cases of chronic brain ischemia.

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