Thromboxane-prostacyclin balance and platelet aggregability in patients with minor cardiac abnormalities
Iagoda, A.V.; Gladkikh, N.N.
Terapevticheskii Arkhiv 82(9): 49-53
2010
ISSN/ISBN: 0040-3660 PMID: 21086621 Document Number: 646402
To reveal changes in the thromboxane-prostacyclin balance and platelet aggregability in patients with various variants of minor cardiac abnormalities. Six-five patients (mean age 23.0 +/- 0.7 years) with minor cardiac abnormalities and 10 apparently healthy individuals were examined. Platelet aggregation induced by adrenaline, adenosine diphosphate, collagen) and the plasma levels of thromboxane B2 (TxB) and 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha) were determined. Patients with abnormally located chordae (ALC) were found to have no deviations in the thromboxane-prostacyclin balance and platelet aggregability. Only decreased collagen aggregation was recorded in the groups of first-degree mitral prolapse (MP) and first-degree MP + ALC; in second-degree MP and second-degree MP + ALC, there was a reduction in platelet aggregation on all inductors and an increase in TxB2. Patients with myxomatous degeneration of the mitral valve exhibited reduced collagen-induced platelet aggregation and lower plasma 6-keto-PGF1alpha levels. The most pronounced changes in the thromboxane-prostacyclin balance and platelet aggregability were found in patients with MP and second-degree regurgitation, three intracardiac micro-abnormalities, and myxomatous degeneration of the mitral valve.