Improvement of prostacyclin-thromboxane A2 balance in patients with acute myocardial infarction by intermittent aspirin
Luo, Y.
Zhonghua Xin Xue Guan Bing Za Zhi 21(4): 219
1993
ISSN/ISBN: 0253-3758 PMID: 8194434 Document Number: 413931
Forty two patients with acute myocardial infarction, (AMI) were, randomly distributed to the following groups: (1) the non-aspirin-treated group; (2) the daily-aspirin-treated group (aspirin, 300mg, once everyday); (3) the intermittent-aspirin-treated group (aspirin, 300mg, once every three days). In addition to the three groups, a group of normal subjects was selected. Blood was taken by venipuncture of the antecubital vein in patients on, the first, second, seventh, forteenth and twenty-first hospitalized days. The plasma levels of 6-keto-prostaglandin F-1alpha(6-keto-PGF-1alpha) and thromboxane B-2(TXB-2) were measured respectively by the scintillation counting of radioimmunoassay. The ratio of 6-keto-PGF-1alpha, to TXB-2 (K/T ratio) was also calculated. Conclusions were as follows: (1) Intermittent treatment with low-dose aspirin is superior to daily treatment in improving the PGI-2/TXA-2 balance in patients with AMI. (2) Daily low-dose aspirin has cumulative inhibitory effects on PGI-2 and TXA-2 synthesis in AMI patients. While intermittent treatment has the same cumulative inhibitory effect on TXA-2 synthesis as daily treatment, but no cumulative inhibitory effect on PGI-2 synthesis.