Significance of plasmic L-plastin levels in the diagnosis of colorectal cancer
Yuan, C.-b.; Zhao, R.; Wan, F.-j.; Cai, J.-h.; Ji, X.-p.; Yu, Y.-y.
Zhonghua Wei Chang Wai Ke Za Zhi 13(9): 687-690
2010
ISSN/ISBN: 1671-0274 PMID: 20878578 Document Number: 646072
To investigate the clinical significance of plasmic L-plastin level in patients with colorectal cancer. From March 2008 to March 2009, plasma samples were collected from 40 patients and 40 healthy controls. Plasmic L-plastin level was measured by ELISA kit and was compared to TIMP-1. Plasmic L-plastin level in patients with colorectal cancer was higher than that in healthy adults (1.662±0.386 vs. 0.485±0.085 μg/L, P<0.01). The sensitivity of L-plastin in the diagnosis of colorectal cancer was 67.5%, and the specificity was 80.6%. The Youden index was 0.481 and AUC was 0.772 (P<0.01). Plasmic L-plastin levels were associated with the tumor size (P=0.006), serosal penetration (F=4.687, P<0.05) and lymphatic metastasis (P<0.01). Compared to plasmic TIMP-1 level, L-plastin showed the same capability in indicating the depth of tumor. The specificity of L-plastin was better in indicating lymphatic metastasis (86% vs. 58%, χ2=4.2, P<0.05). Plasmic L-plastin level may serve as a potential marker in colorectal cancer.