Prognostic significance of the p185 protein in colorectal cancer
Sanz-Casla, M.T.; Vidaurreta, M.; Maestro, M.L.; López, J.A.; Jiménez, F.; Fernández, C.; Maestro, C.; Balibrea, J.L.; Cerdán, F.J.
Revista Espanola de Enfermedades Digestivas Organo Oficial de la Sociedad Espanola de Patologia Digestiva 96(2): 102-109
2004
ISSN/ISBN: 1130-0108 PMID: 15255019 Document Number: 579963
The amplification and/or overexpression of the c-erbB-2/neu oncogene may play a role in tumor development and progression. The aim of this prospective study was to evaluate the prognostic value of p185 protein in colorectal cancer using immunohistochemical techniques. We analyzed 106 colorectal tumor tissue specimens from patients who had been operated on by the same surgeon and subjected to a median follow-up of 3 years. Thirty-three per cent of patients showed p185 overexpression related to an advanced stage of the disease. In patients with adenocarcinoma tumors of the colon without distant metastases, p185 detection was found to be of clinical prognostic relevance (p = 0.06).