Prognostic significance of subclassification of stage IV gastric cancer according to pTNM categories
An, Q.; Song, X.; Li, Y.; Shi, X.-Y.
Hepato-Gastroenterology 57: 102-103
2010
ISSN/ISBN: 0172-6390 PMID: 21410081 Document Number: 645795
The aim was to evaluate the surgical outcome and prognosis of patients with stage IV gastric cancer, and to investigate whether stage IV gastric cancer should be further subclassified for more accurate prediction of outcome. We analyzed 401 patients with stage IV gastric cancer who underwent gastric resection from 1998 to 2004. According to TNM categories, we separated them into T1-3N3M0, T4N1-2M0, T4N3M0, And TanyNanyM1 groups. The survival rate of patients with subclassification IVa (T1-3N3M0 and T4N1-2M0) gastric cancers was significant higher than that of patients with sub-classification IVb (T4N3M0 and TanyNanyM1) ones (p < 0.001). Multivariate analysis showed that sub-classification, distant metastasis, and curability of operation were significant factors affecting survival. Sub-classification of stage IV gastric cancer into a relatively favorable group (T4N1-2M0 and T1-3N3M0; stage IVa) and an unfavorable group (T4N3M0 and TanyNanyM1; stage IVb) may predict patients' prognosis more accurately.