Angiogenesis and antiangiogenesis in intraocular tumors
Macovei, L.
Oftalmologia 54(4): 24-26
2010
ISSN/ISBN: 1220-0875 PMID: 21516858 Document Number: 645514
Angiogenesis, fundamental process that consists in the formation of new vessels, is essential physiologically in the tissue maintenance and of the homeostasis, having in this sense a few positive and negative regulators. Vascular endothelial growth factor and other angiogenical proteins play a major role in the ocular and general angiogenesis. The solid tumors need new vessels in order to survive and grow, therefore the anti-angiogenic agents can represent important instruments in the ocular oncological therapy The intravitreal administration of the anti-VEGF agents delay the growth of the intraocular tumors, decreases the odds of their methastasis at distance, increases the therapeutical effects of the conservative treatment by irradiation and can limit the ocular complications of radiotherapy.