Age-related changes in the level of serum bone markers in healthy children
Ivashkina, T.M.; Kotova, T.N.; Omarova, P.S.; Khlekhlina, I.V.; Berestovskaia, V.S.; Ponkratova, T.S.
Klinicheskaia Laboratornaia Diagnostika 11: 7-10
2010
ISSN/ISBN: 0869-2084 PMID: 21313747 Document Number: 645266
Age-related changes in the blood level of bone metabolic markers were compared in healthy children living in different geographical regions. The absolute value of carboxy-terminal telopeptide of type 1 collagen type 1 (beta-CrossLaps) and that of total procollagen type 1 amino-terminal propeptide (PINP) were found to depend on living conditions and the nature of changes in the serum markers of bone metabolism was related to the processes of natural growth and development in children. A child's individual growth curve can be used to identify target groups for the prevention of osteopenia.