Partial breast irradiation (PBI) : the therapy of the future?
Koning, C.C.E.; Bijker, N.; van Tienhoven, G.
Nederlands Tijdschrift Voor Geneeskunde 154: A2593
2010
ISSN/ISBN: 1876-8784 PMID: 21083961 Document Number: 644294
Breast-conserving therapy with radiation therapy of 50 Gy over 5 weeks to the entire breast plus a tumour bed boost is the standard treatment for patients with early stage breast cancer. Several attempts have been made to lower the treatment burden, such as omitting either all radiotherapy or the tumour bed boost, without success. Phase III trials are now being carried out to evaluate the treatment of the primary tumour area only (PBI). Various methods for selection of patient groups and of delivering the radiation dose have been employed. Vaidya et al. report the same favourable local recurrence rates following PBI with single dose intraoperative radiotherapy as with whole-breast irradiation. As the follow-up period so far has been short, long-time results should be awaited.