Animal cell substrates: back to the future
Petricciani, J.
PDA Journal of Pharmaceutical Science and Technology 64(5): 375-378
2010
ISSN/ISBN: 1948-2124 PMID: 21502040 Document Number: 643825
The acceptability of animal cell substrates for the manufacture of biological products, especially vaccines, has been an issue in one form or another since the development of cell cultures in the 1950s. Here the major cell substrate events of the past 50 years are briefly reviewed, and recent progress in resolving longstanding issues is highlighted.
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