Is autosomal dominant polycystic kidney disease associated with asymptomatic bacteriuria?
Pietrzak-Nowacka, M.; Giedrys-Kalemba, S.; Safranow, K.; Szymaniak, L.ła.; Nowosiad, M.; Korzonek, M.; Sulikowski, T.; Ciechanowski, K.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 29(171): 173-176
2010
ISSN/ISBN: 1426-9686 PMID: 20931827 Document Number: 642970
Urinary tract infections (UTIs) are a common complication in patients with autosomal dominant polycystic kidney disease (ADPKD). Asymptomatic bacteriuria (AB) is a factor predisposing to UTI in other populations. The aim of the study was to determine whether AB is more frequent in a group of ADPKD patients with normal kidney function and no diabetes than in a healthy control group. A group of 49 ADPKD patients (19 men and 30 women) with normal kidney function (creatinine level < 1.35 mg/dl) and no diabetes, with an average age of 35.9 +/- 11.1 years was compared with a group of 50 healthy controls (22 men, 28 women) with similar age (36.7 +/- 9.2 years). All subject were evaluated using medical history and physical examination, urine culture, urinalysis (biochemical and morphological), kidney ultrasonography, oral glucose tolerance test (with 75 g of glucose) and serum creatinine testing. UTIs were significantly more frequent in medical history of ADPKD patients than in control group (26% vs. 0%, p < 0.001). Asymptomatic bacteriuria was found in 2% of ADPKD patients and in 4% of control group (p = 0.69). The presence of protein in urinalysis was observed in 6% of ADPKD and in none of the control patients. Other urine measurements like pH, specific gravity, and morphological examination were normal and did not substantially differ between groups. The kidneys of ADPKD patients were significantly longer than in control group (p < 0.001). Asymptomatic bacteriuria is not present more frequently in ADPKD patients with normal kidney function and no diabetes, than in healthy people.