HPLC and TLC enantioseparation of the nitro-positioned aryloxysubstituted aminopropanols
Cizmáriková, R.; Bruchatá, K.; Pastírová, Z.; Lehotay, J.; Hrobonová, K.
Die Pharmazie 65(5): 387-388
2010
ISSN/ISBN: 0031-7144 PMID: 20503935 Document Number: 641803
An enantioseparation study of nitro-substituted aryloxyaminopropanols was performed using HPLC on a teicoplanin chiral stationary phase and TLC impregnated with L-aspartic and L-tartaric acid as chiral selectors. The type of substituent on the nitrogen in the hydrophilic part of molecule is essential for excellent separation by HPLC. L-aspartic acid seems to be a suitable chiral selector for enantioseparation by TLC.
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