Potential role of immunoablation and hematopoietic cell transplantation in the treatment of early diabetes type 1
Snarski, E.; Milczarczyk, A.; Franek, E.; Jedrzejczak, W.
Annals of Transplantation 15(3): 75-79
2010
ISSN/ISBN: 2329-0358 PMID: 20877271 Document Number: 640121
Immunoablation with autologous hematopoietic cell transplantation has shown some effectiveness in the treatment of autoimmune diseases as diverse as aplastic anemia, systemic lupus erythematosus, multiple sclerosis and Crohn's disease. It has been recently shown that this treatment might prevent or delay development of diabetes type 1. The majority of more than 30 patients with early diabetes type 1 who underwent immunoablation and hematopoietic cell transplantation in various centers in the world achieved durable remission of diabetes and independence of exogenous insulin. This review summarizes advantages and risks of this treatment of early diabetes type 1.