Mineral and bone disturbances associated with chronic kidney disease
Suchowierska, E.; Myśliwiec, M.ł
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 28(164): 138-143
2010
ISSN/ISBN: 1426-9686 PMID: 20369744 Document Number: 639313
In the course of chronic kidney disease (CKD) comes to the disturbances in mineral and bone metabolism and extra-skeletal calcification. In subsequent stages of CKD, these processes intensify, leading to a deterioration in the quality of life and disability. They are also a major cause of morbidity and mortality from cardiovascular causes in CKD. In 2005, the Organization of Kidney Disease: Improving Global Outcomes (KIDGO), proposed replacing the term Renal Osteodystrophy in mineral and bone complications CKD (chronic kidney disease mineral and bone related disorders; CKD-MBD) as the disorder is not confined to the skeleton. CKD-MBD is manifested by the presence of changes in laboratory tests (corrected serum calcium, organic phosphate, parathyroid hormone, concentrations of vitamin D derivatives), changes in bone (bone metabolism, bone mineralization and trabecular bone volume), the occurrence of calcifications in the soft tissues and the arterial vessels.