Assessment of immune disorders in patients presenting with various forms of chronic suppurative otitis media in the postoperative period
Poliakova, S.D.; Popova, E.A.; Rodinko, I.P.
Vestnik Otorinolaringologii 5: 41-43
2010
ISSN/ISBN: 0042-4668 PMID: 21191352 Document Number: 638918
The present study was designed for immunological examination of 46 patients presenting with various forms of chronic suppurative otitis media. All the patients underwent surgical intervention on mastoid process (processus mastoideus). It was shown that exacerbation of catarrhal inflammation provoked a significant decrease of the total lymphocyte, T-helpers, and B-lymphocyte (CD22) count whereas the concentration of T-suppressors increased. In patients with the distractive form of chronic suppurative otitis media, the absolute number of total lymphocytes, T-lymphocytes, T-helpers, and B-lymphocytes was also reduced while the concentration of IgG was elevated. The level of serum cytokines (IL-1-beta, IL-6, TNF-alpha) increased in both forms of the disease although the rise in case of catarrhal inflammation was much more pronounced. These data suggest beneficial effect of supplemental corrective immunotherapy.