Electrophysiological evaluation of the hearing function following cisplatin administration
Bogomol'skiĭ, M.R.; D'iakonova, I.N.; Rakhmanova, I.V.; Sapozhnikov, I.M.; Stakhovskaia, O.R.; Tikhomirov, A.M.
Vestnik Otorinolaringologii 3: 24-26
2010
ISSN/ISBN: 0042-4668 PMID: 20559247 Document Number: 638899
Experiments on guinea pigs with the use of electrophysiological methods (short-latency auditory evoked potentials, SLAEPs, and distortion product otoacoustic emission, DPOAE) have demonstrated damage of outer hair cells following application of therapeutic doses of cisplatin. It is concluded that finding of the logarithmic amplitude-time dependence for the first SLAEPs peak permits to diagnose an injury to outer hair cells.