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Metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces

Zhang, L.; Xiang, C.; Wang, B.; Zhao, Y.; Zhang, Q.

Zhongguo Zhong Yao Za Zhi 34(3): 340-343

2009

ISSN/ISBN: 1001-5302
PMID: 19445163
Document Number: 637928
To study the metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces. The urine and feces of rats were collected at different times after orally administration of total flavonoids from Semen Ziziphi Spinosae, disposed by HP-20 macroporous resin, and then detected by both HPLC and LC-MSn methods. Two main proto-drugs, spinosin and 6'"-feruloylspinosin, along with a metabolite, swertish (M1), are detected in both urine and feces of rat. Flavonoids of Semen Ziziphi Spinosae are excreted in urine and feces mainly in form of proto-drug, while little in form of metabolites, such as swertish.

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