Total-tau and phospho-tau (181Thr) in cerebrospinal fluid of neurologically intact population increase with age
Jaworski, J.; Psujek, M.; Bartosik-Psujek, H.
Folia Biologica 55(4): 126-131
2009
ISSN/ISBN: 0015-5500 PMID: 19691919 Document Number: 637494
Tau protein is a microtubule-associated molecule playing a crucial role in maintenance of neuronal integrity and in many neurodegenerative processes; its pathology has become a hallmark feature at the tissue level. The aim of the study was to estimate total tau and phospho-tau (Thr181) concentrations in cerebrospinal fluid of healthy population. Cerebrospinal fluid samples were taken from 129 subjects (age 18-77 years) without known neurologic or psychiatric condition. Both total-tau and phospho-tau levels showed significant correlation with age, which was more pronounced in older population.