The effects of arterial carbon dioxide tension on an increase in cerebrospinal fluid pressure induced by nicardipine
Nishikawa, T.; Namiki, A.; Omote, K.
Masui. Japanese Journal of Anesthesiology 37(2): 176-179
1988
ISSN/ISBN: 0021-4892 PMID: 3131558 Document Number: 315910
The effects of arterial carbon dioxide tension upon increase in cerebrospinal fluid pressure (CSFP) after nicardipine, a calcium entry blocker were studied in halthane anesthetized dogs. CSFP was measured continuously by a catheter placed in the cisterna magna. CSFP significantly increased after nicardipine 0.02 mg/kg given intravenously, as a bolus (P<0/01). The increases in CFSP from the control values were 4.8.+-.2.8 mmHg (mean .+-. SD) in normocapnic group (n=7, PaCO2 40.1 .+-. 1.3 mmHg), and 2.3 .+-. 1.0 mmHg in hypocapnic group (n=7, PaCO2 23.8.+-.0.6 mmHg), respectively. Thus, the magnitude of increases in CSFP after nicardipine was significantly smaller in hypocarpnic group than in normocapnic group (P<0.05). The decreases in mean arterial pressure and cerebral perfusion pressure after nicardipine were similar in both groups. This study suggests that hyperventilation is one of the useful techniques for attenuating the increases in CSFP caused by nicardipine.