Preparation and prescription of enteric coated pellets of Panax notoginseng saponins pellets
Lai, C.; Zheng, Q.; Yang, M.; Hu, P.; Pan, J.; Peng, C.
Zhongguo Zhong Yao Za Zhi 34(11): 1359-1363
2009
ISSN/ISBN: 1001-5302 PMID: 19771862 Document Number: 634595
To prepare enteric coated pellets containing panax notoginseng saponins. Panax notoginseng saponins loaded pellets were prepared by Extrusion-Spheronization method, and coated by Eudragit L30D-55 using Glatt fluid bed with the bottom spray process, central composite design was used to optimize the coating prescription. The drug release of enteric coated pellets of panax notoginseng saponins pellets would be lower than 5% in 2 h in simulated gastric fluid, but reach above 85% in 3 h in simulated human gastroenteric environment. The enteric coated pellets of panax notoginseng saponins have good acid residence to avoid panax notoginseng saponins from degrading in gastric acid.