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The pharmacokinetics and pharmacodynamics of intranasal preparation of Panax notoginseng Saponins

Wu, Y-juan.; Zhu, X-yi.; Sha, X-yi.; Fang, X-ling.

Yao Xue Xue Bao 40(4): 377-381

2005

ISSN/ISBN: 0513-4870
PMID: 16011272
Document Number: 593660
A study was conducted to investigate the pharmacokinetic course of intranasal powders of Panax notoginseng [P. pseudoginseng var. notoginseng] saponins (PNS) in a rat model and its protective effects against cardio-cerebrovascular diseases administrated in the form of its suspension. After administration, Rg1 concentration in the serum was analysed by HPLC and the absolute bioavailability was calculated. The protective effects against cardio-cerebrovascular diseases were studied on acute myocardial infarction model in rats built by occlusion of left coronary artery and cerebral ischaemia-reperfusion model in gerbils built by occlusion of bilateral common carotid artery (CCA). The in vivo course of Rg1 in rats conformed to two-compartment model after intranasal administration of PNS suspension and the absolute bioavailability was 103.56%. The suspension significantly reduced myocardial infarct size induced by occlusion of the left coronary artery, alleviated cerebral oedema and the stroke symptoms induced by occlusion of bilateral CCA. The effects were dose-dependent, the higher the dose, the better the effects. The results of pharmacokinetics and pharmacodynamics demonstrated that PNS intranasal preparation has a pretty prospect to develop.

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