Pitfalls in the diagnosis of tick-borne encephalitis in vaccinated patients
Zelená, H.; Januska, J.Ã; Raszka, J.
Klinicka Mikrobiologie a Infekcni Lekarstvi 15(4): 151-154
2009
ISSN/ISBN: 1211-264X PMID: 19937579 Document Number: 633498
The authors draw attention to diagnostic pitfalls in tick born encephalitis serology in vaccinated people. Benefits and limitations of particular serologic methods are demonstrated by case study of a patient with a failure of anti-TBEV vaccination. It is necessary to examine paired serum samples in previously vaccinated patients with suspicion of tick born encephalitis and to demonstrate significant increase of antibodies titers for confirmation of the diagnosis. The virusneutralisation assay is considered a method of choice in these special cases.