Immunogenetic criteria for prediction of mixed hepatitis a + B
Bondarenko, A.L.; Ustiuzhaninov, V.N.; Vozhegova, N.P.; Strazhnikova, G.A.
Klinicheskaia Laboratornaia Diagnostika 4: 30-32
2009
ISSN/ISBN: 0869-2084 PMID: 19514333 Document Number: 633441
The investigation has revealed that mixed hepatitis A + B is a genetically determined disease. HLA-A10, B21, Cw2, Cw5, A10-A19, B8-B13, B21-B35, A3-B21, and A9-B21 are immunogenetic markers of this disease. The carriers of HLA-B21, Cw5, A3-B21, and A9-B21 and those of HLA-A10, A10-A19, and A10-B14 are at high risk for this infection among men and women, respectively. The findings of the distribution of HLA antigens and their combinations in mixed infection with hepatitis A and B viruses allow prediction of its occurrence (including the consideration of examinees' gender) which will assist in solving the matter of timely prophylaxis of this pathology.