Association of the T (-365) C POLG1, G (-25) A ANT1 and G (-605) T PEO1 gene polymorphisms with diabetic polyneuropathy in patients with type 1 diabetes mellitus
Spitsina, E.V.; Svetlova, G.N.; Chudakova, D.A.; Nikitin, A.G.; Kuraeva, T.L.; Strokov, I.A.; Nosikov, V.V.
Molekuliarnaia Biologiia 43(2): 378-382
2009
ISSN/ISBN: 0026-8984 PMID: 19425506 Document Number: 632569
The aim of this study was the search of association of polymorphic markers T(-365)C of POLG1 gene, G(-25)A of ANT1 gene and G(-605)T of PEO1 gene with diabetic polyneuropathy (DPN) in type 1 diabetes mellitus (T1DM) patients. All patients were ethnic Russians from Moscow, with a T1DM record of no more than 5 years and DPN or a T1DM record of more than 10 years but without DPN. We have found that polymorphic marker T(-365)C of POLG1 gene was associated with DPN in Russian patients with T1DM. The carriers of C allele and CC genotype had higher risk of DPN development (OR = 1.62; CI = 1.11-238; and OR = 1.76; CI = 0.99-3.13; relatively). On the contrary, the carriage of T allele and TT genotype were associated with the lower risk of DPN development (OR = 0.62, CI = 0.42-0.90; and OR = 0.61; CI = 035-1.07; relatively). We have not found any association of polymorphic markers G(-25)A of ANT1 gene and G(-605)T of PEO1 gene with DPN in Russian patients with T1DM living in Moscow.