Local thrombolysis of sinus thrombosis
Soll, N.H.øj.; Vestergård, K.; Nepper-Rasmussen, J.ør.
Ugeskrift for Laeger 171(45): 3284-3285
2009
ISSN/ISBN: 1603-6824 PMID: 19887060 Document Number: 632485
A 16-year-old girl was diagnosed with widely distributed dural sinus thrombosis (DST) and a haemorrhagic infarct in the left parietal lobe. Despite of heparin treatment, pronounced aggravation of symptoms was observed. Through a femoral vein approach a micro-catheter was advanced into the superior sagittal sinus and rt-PA was infused slowly, directly into the thrombus over 24 hours. A follow up angiogram showed recanalisation of sinus. The patient recovered almost completely, with only few remaining cognitive symptoms. This treatment remains experimental, but should be kept in mind for DST-patients unresponsive to heparin treatment.