Local intra-arterial thrombolysis in acute ischemia of an extremity
Enevoldsen, M.T.; Rørdam, P.; Schroeder, T.V.
Ugeskrift for Laeger 158(36): 5011-5014
1996
ISSN/ISBN: 0041-5782 PMID: 8928238 Document Number: 456566
The effect of intra-arterial local thrombolysis or peripheral arterial occlusions seems to be well documented. As assessed by angiography, primary recanalisation is achieved in 65-90%. Using recombinant tissue plasminogen activator thrombolysis is achieved more frequently (90% vs 65-85%) and faster (4-8 hours vs 12-48 hours) than when using streptokinase or urokinase. The most frequently used dosages are streptokinase 5000 IU/h, and recombinant tissue plasminogen activator 0.5 mg/h. So far, results from randomized trials between thrombolytic therapy and surgery have not been published.