Role of connexin 26 (GJB2) and mitochondrial small ribosomal RNA (mt 12S rRNA) genes in sporadic and aminoglycoside-induced non syndromic hearing impairment
Lingala, H.B.; Penagaluru, P.R.
Indian Journal of Medical Research 130(4): 369-378
2009
ISSN/ISBN: 0019-5340 PMID: 19942739 Document Number: 632109
Non syndromic hearing impairment is a common sensory disorder, which affects one in 600 newborns. Though more than 50 nuclear genes are involved in causing non syndromic hearing impairment, mutations in the connexin 26 (GJB2) gene explain a high proportion of congenital deafness in several populations worldwide. The diversity of genes and genetic loci implicated in hearing loss defines the complexity of the genetic basis of hearing. This review focuses on the role of connexin 26 and mitochondrial 12S rRNA genes in hearing which will be helpful for better understanding of genes in sporadic and aminoglycoside-induced non syndromic hearing impairment.