Effects of calcium and vitamin D supplementation on bone specific alkaline during pregnancy lactation and infant
Wang, J.; Li, H.; He, Q.; Ren, C.
Wei Sheng Yan Jiu 38(2): 193-195
2009
ISSN/ISBN: 1000-8020 PMID: 19408664 Document Number: 631897
To investigate the effect of calcium and vitamin D supplementation during pregnancy, lactation and infants on bone development of infant. 1176 health infants aged 42-365 days and their mothers were recruited as subjects at Pediatric Department in Beijing Obstetrics and Gynecology Hospital during November 2006 to January 2008. Retrospective questionnaire was asked about calcium and vitamin D supplementation during pregnancy, lactation and infant. Blood bone-specific alkaline (BAD) and fontanel anterior (FA) of infant were measured. Chi2 test and logistic regression were used to analyze the research data. The chi2 test result showed that maternal supplementation with Ca and vitamin D during breastfeeding could decrease infant BAP significantly (P = 0.018), while supplementation during pregnancy could not (P = 0.154). The logistic regression result showed that infant supplementation with Ca and Vitamin D could decrease infant BAP significantly (P = 0.000), while infant feeding methods could not (P > 0.05). The FA size of infants aged < or =42 days had significant negative relationship with BAP (P = 0.017), and no relationship with Ca and vitmin D supplementation during pregnancy. Supplementation with Ca and vitamin D of mother during lactation and infant could significantly decrease infant BAD. The FA size could not indicate the infant calcium status.