Pathogenesis of posterior capsule opacification in pseudophakia
Łukaszewska-Smyk, A.; Kałuzny, Józef.
Klinika Oczna 111(10-12): 369-374
2009
ISSN/ISBN: 0023-2157 PMID: 20169899 Document Number: 630602
The lens epithelial cells of A and E type are involved in pathogenesis of posterior capsule opacification (PCO). They undergo metaplasia into microfibroblasts, then migrate towards posterior capsule where they proliferate and form opacification. These processes are stimulated by cytokines and interleukines. The extracellular matrix which constitutes a scaffold for migration and attachment of epithelial cells plays an important role in PCO formation. Integrines intercede in this process.