Disorders with elevated immunoglobulin e levels
Nowicka, U.
Pneumonologia i Alergologia Polska 77(6): 533-540
2009
ISSN/ISBN: 0867-7077 PMID: 20013704 Document Number: 630428
Immunoglobulin E (IgE) was first described in 1967. It has the lowest serum concentration of all circulating immunoglobulin isotypes. Serum IgE concentration at birth is low and rises until the age of 10-15 years. The increment of serum IgE in children with predisposition to atopic reactions is usually more abrupt. Total serum IgE levels decline from the second to the eight decade of life. Usually, elevated IgE concentration is related to atopic diseases but there are many other disorders combined with elevated serum IgE (for example: infections, neoplasms, immunodeficiency syndromes, skin disorders, inflammatory diseases). The spectrum of diseases combined with serum IgE elevation was presented in the present article.