On the possibility of patient phenotyping on the basis of cytochrome p-450 1A2 isoenzyme activity using caffeine as the test substrate
Filimonova, A.A.; Ziganshina, L.E.; Ziganshin, A.U.; Chichirov, A.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 72(5): 61-65
2009
ISSN/ISBN: 0869-2092 PMID: 19928580 Document Number: 630040
Reactions of caffeine biotransformation and enzymes participating in the caffeine metabolism via the paraxanthine pathway are reviewed. Data on the drugs metabolized mainly in cytochrome P-450 1A2 isoenzyme (CYP 1A2) are analyzed. Information on the phenotypes of CYP 1A2 activity in smoking healthy volunteers, women using oral contraceptives, diabetes patients, those with liver disorders, etc. is summarized. Methodological approaches to patient phenotyping with respect to CYP 1A2 activity as proposed in the available literature are analyzed.