Case report on hereditary non-polyposis colon cancer (HNPCC) in Nigeria
Adebamowo, C.A.; Adeyi, O.; Pyatt, R.; Prior, T.W.; Chadwick, R.B.; de la Chapelle, A.
African Journal of Medicine and Medical Sciences 29(1): 71-73
2000
ISSN/ISBN: 0309-3913 PMID: 11379475 Document Number: 6300
The role of genetic factors in the etiology of colorectal cancers (CRCs) has recently been elucidated with the discovery of the mismatch repair. These genes are responsible for less than 5% of all cases of CRCs in Caucasian series. In this pilot study, tumors from 5 randomly ascertained CRC patients were subjected to microsatellite analysis, and two were microsatellite unstable. Both of these two patients had germline mutations in MSH2. If this finding can be confirmed in a larger series of patients, it suggests that MMR genes play an important role in the etiology of CRCs in Africa.
Document emailed within 1 workday
