Optimization of matrix formulation of effective parts cataplasm of Pogostemon cablin by uniform design
Wang, X.-G.; Zou, Y.-F.; Chen, Y.-Z.
Zhongguo Zhong Yao Za Zhi 33(6): 638-641
2008
ISSN/ISBN: 1001-5302 PMID: 18590189 Document Number: 627467
To optimize the matrix formulation of the effective part Cataplasm of Pogostemon Cablin. The optimal preparation prescription was selected by U17 (17(11)) uniform design,and the tacking strength, cohesive strength and transdermal speed constant were used as test indexes. The equations of three test indexes were established by SPSS. With analysis of the contribution of factors by SPSS regression, the optimal matrix formulation was acquired. The optimal matrix formulation is carbopol U10-NoveriteTM7s-glycerine-sorbitol-kaolin-citric acid-aluminum trichloride (1.0:5.0:20:2.0:2.0:0.25:0.2). The matrix has good adhesive property, proper drug release rate, desirable hemocompatibility with the extractions of Pogostemon cablin.