Selective targeting of GnRH-Ii neurons to block ovulation
Urbanski, H.F.
Contraception 91(5): 423-425
2015
ISSN/ISBN: 1879-0518 PMID: 25444718 DOI: 10.1016/j.contraception.2014.09.010Document Number: 626563
In rhesus macaques, luteinizing hormone (LH) secretion appears to be regulated by two distinct gonadotropin-releasing hormone (GnRH) neuronal populations, which can be distinguished by their unique anatomical locations and because they express different molecular forms of GnRH (GnRH-I and GnRH-II). The effect of estradiol on GnRH gene expression was examined. Estradiol inhibited GnRH-I neurons but stimulated GnRH-II neurons, suggesting that GnRH-II neurons play the dominant role in mediating estradiol-positive feedback and triggering the midcycle preovulatory LH surge. Selective silencing of GnRH-II neurons in women could serve as a novel contraceptive, by blocking ovulation while leaving the rest of the reproductive axis relatively unperturbed.
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