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Curcumin inhibits growth, induces G1 arrest and apoptosis on human prostatic stromal cells by regulating Bcl-2/Bax

Chen, Z.-q.; Jie, X.; Mo, Z.-n.

Zhongguo Zhong Yao Za Zhi 33(16): 2022-2025

2008

ISSN/ISBN: 1001-5302
PMID: 19086645
Document Number: 623907
To investigate the effect of curcumin on apoptosis of human prostatic stromal cells. Different concentrations of curcumin were added into culture media system to induce apoptosis of human prostatic stromal cells. The apoptosis was detected by MTT assay, flow cytometry, RT-PCR and TUNEL method. Curcumin at concentrations of 10-40 micromol x L(-1) could inhibit the proliferation of human prostatic stromal cells in a doseand time-dependent manner (P < 0.05). Characteristic apoptosis were confirmed by TUNEL RT-PCR manifest downregulation of Bcl-2/Bax (P < 0.05). Cell cycle was arrested into G1 phase by curcumin. Curcumin can induce apoptosis in human prostatic stromal cells by down-regulation of Bcl-2/Bax.

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