A comparative study of the serological response to Japanese encephalitis vaccine in HIV-infected and uninfected Thai children
Chokephaibulkit, K.; Plipat, N.; Yoksan, S.; Phongsamart, W.; Lappra, K.; Chearskul, P.; Chearskul, S.; Wittawatmongkol, O.; Vanprapar, N.
Vaccine 28(20): 3563-3566
2010
ISSN/ISBN: 1873-2518 PMID: 20226889 DOI: 10.1016/j.vaccine.2010.02.108Document Number: 623535
We report a prospective study of mouse brain derived inactivated Japanese encephalitis (JE) vaccine, given in 3-dose EPI program to human immune deficiency virus (HIV)-exposed Thai infants. 18 HIV-infected receiving antiretroviral therapy with median baseline CD4 of 33.1%, and 92 HIV-uninfected children were studied. All but one HIV-infected child seroconverted after the second dose. The geometric mean titers (GMTs) 3 months after the second and third doses in HIV-infected vs HIV-uninfected children were 247 vs 938 (p=0.022), and 2273 vs 24069 (p=0.009), respectively. Urticaria or angioedema found in 4% and 6% in HIV-infected and -uninfected children, respectively (p=1.0). The vaccine was safe and immunogenic but antibody response in HIV-infected children was not as high as in uninfected children.
Document emailed within 0-6 h
