Prediction of the B cell epitopes for the major outer membrane protein of Chlamydia trachomatis
Zhu, S.; Shi, Z.; Wang, P.; Li, W.; Zhang, L.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 25(6): 1397-1400
2008
ISSN/ISBN: 1001-5515 PMID: 19166217 Document Number: 623088
To predict the B cell epitopes for major outer membrane protein (MOMP) of Chlamydia trachomatis (CT), the secondary structure of CT MOMP was predicted by the methods of GOR based on the sequence of amino acids of E serotype CT MOMP. By combining the comprehensive analysis of transmembrane domain, hydrophilicity profile, surface probability, antigenic index and average flexibility, the B cell predominant epitopes of CT MOMP were further predicted. The N-terminal No. 73-81, 217-225, 377-386, 261-270 and 161-175 were the predominant B cell epitopes. Prediction of the B cell epitopes for the CT MOMP by the multi-parameters is helpful for the identification of B cell epitopes.