Unusual associations of pachydermoperiostosis: a case report
Kumar, U.; Bhatt, S.Prakash.; Misra, A.
Indian Journal of Medical Sciences 62(2): 65-68
2008
ISSN/ISBN: 0019-5359 PMID: 18319534 Document Number: 622098
Primary hypertrophic osteoarthropathy (HOA), or pachydermoperiostosis, is a rare benign disorder of unknown etiology. It is characterized by clubbing, periosteal reaction, and thickening of the skin. Disease usually progresses slowly, and natural arrest may occur. Reported herein is the case of a 28-year-old male patient with progressively increasing swelling of large joints of lower limbs with severe anemia. He was diagnosed as a case of pachydermoperiostosis with myelofibrosis, which is a rare association. The development of myelofibrosis makes primary HOA a disease with unfavorable outcome.