Photodynamic effect of lanthanide derivatives of meso-tetra (N-methyl-4-pyridyl) porphine against Staphylococcus aureus
Jurczak, A.; Szramka, B.; Grinholc, M.; Legendziewicz, J.; Bielawski, K.P.
Acta Biochimica Polonica 55(3): 581-585
2008
ISSN/ISBN: 0001-527X PMID: 18726009 Document Number: 621725
Photodynamic therapy (PDT), used for cancer treatment, is also an alternative method for eradication of drug-resistant bacteria. This method utilizes a nontoxic light-activated dye, called a photosensitizer, and visible light to produce reactive oxygen species that lead to bacterial cell death. The purpose of this study was to investigate the bactericidal effect of PDT using lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus strains. The new photosensitizers appeared to be photodynamically ineffective. No enhancement of antistaphylococcal activity of TMPyP was observed after the conjugation of the porphyrin with lanthanide ions. Additionally, a significant difference in the susceptibility of two bacterial strains to unmodified TMPyP was observed.